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Multiple sclerosis

More than 2 million people suffer from multiple sclerosis in the world. The annual Incidence is approximately 3.5-5 new cases per 100 thousand population, and during the last few decades the Prevalence and Incidence of multiple sclerosis has been steadily growing. In 2014 in Ukraine, 19.114 patients with multiple sclerosis were registered among the adult population, that accounts for 54.1 patients per 100 thousand population. Each year the number of patients with multiple sclerosis increases on average by 1000-1200 patients. In 2014 the Incidence amounted to 3.4 per 100 thousand population in Ukraine. Depending on the region of Ukraine, the Prevalence of the disease varies from 28 to 90 patients per 100 thousand population. Multiple sclerosis in Ukraine holds the 2nd place with disability among diseases of the nervous system. Although pediatric multiple sclerosis is a rare disease, the first symptoms appear at the age under 18 years in 2-10% of patients with multiple sclerosis. Read more

Standardization of medical care

  • The draft order of MoH of Ukraine “On approval and implementation of medico-technological documents on standardization of medical care in Multiple sclerosis”Read more

Clinical trials including adults /in adults, adults & children/

  • Globally, there are 186 recruiting clinical trials for Multiple sclerosis, including 32 Phase I and 18 Phase IV trials at ClinicalTrials.gov.
  • World leaders: the USA – 91, France – 34, Germany – 22 recruiting trials.
  • CEE leaders: Poland – 7, Hungary – 6, Bulgaria – 5 recruiting trials.
  • Ukraine: Not yet recruiting – 0; Recruiting – 2; Active, not recruiting – 16 clinical trials.

There are 2 recruiting Phase III clinical trials conducted on 27 clinical sites in 16 cities: Zaporizhia – 4, Kyiv/Odesa – 3, Chernihiv/Ivano-Frankivsk/Kharkiv/Lviv – 2 sites. The country experience includes 66 Phase II, III and IV clinical trials for Multiple sclerosis totally conducted on 36 clinical sites in 19 cities (accounted for 61 of 66 trials). The city leaders by the number of clinical trials: Kharkiv – 51, Kyiv – 48, Lviv – 38 trials. The city leaders by the number of clinical sites: Kyiv/Zaporizhia – 4, Dnipro/ Kharkiv/Lviv/Odesa – 3, Chernihiv/Ivano-Frankivsk/Lutsk – 2 sites.

Clinical trials on medical devices

  • Globally, there are 28 recruiting clinical trials, including 1 Phase I trial.
  • World leaders: the USA – 14, France – 4, Belgium/Italy – 3 recruiting trials.
  • CEE leaders: no recruiting clinical trials.

Clinical trials with stem cells

  • Globally, there are 16 recruiting clinical trials, including 7 Phase I trials.
  • World leaders: the USA – 6, Canada/the United Kingdom – 2 recruiting trials.
  • CEE leaders: no recruiting clinical trials.

clinical trials for multiple sclerosis incl adults in CEE

clinical trials for multiple sclerosis incl adults in Ukraine

recruiting trials for multiple sclerosis incl adults in Ukraine

clinical sites in trials for multiple sclerosis incl adults in Ukraine


Clinical trials including children /pediatric, in children & adults/

  • Globally, there are 17 recruiting clinical trials for Multiple sclerosis; Phase I – 0, Phase IV – 1 trial at ClinicalTrials.gov.
  • World leaders: the USA – 8, Canada/Germany/the United Kingdom – 5, Belgium/France – 4 recruiting trial.
  • CEE leaders: Bulgaria/Poland – 3, Austria/Estonia/Lithuania/Serbia/the Russian Federation – 2 recruiting trials.
  • Ukraine: Not yet recruiting – 0; Recruiting – 1; Active, not recruiting – 1 clinical trial.

There is 1 recruiting Phase III clinical trial conducted on 8 clinical sites in 7 cities (Kharkiv – 2 cities).

The country experience includes 3 Phase III clinical trial for Multiple sclerosis totally conducted on 16 clinical sites in 12 cities. The city leaders by the number of clinical trials: Kharkiv/Kyiv/Lviv – 3 trials. The city leaders by the number of clinical sites: Kharkiv – 3, Kyiv/Zaporizhia – 2 sites.

Clinical trials on medical devices

  • Globally, there are 3 recruiting clinical trials; Phase I trials – 0.
  • World leaders: Italy – 2, the Islamic Republic of Iran – 1 recruiting trial.
  • CEE leaders: no recruiting trials.

Clinical trials with stem cells

  • Globally, no recruiting clinical trials.

clinical trials for multiple sclerosis incl children in CEE

clinical trials for multiple sclerosis incl children in Ukraine


Non-interventional studies including adults /in adults, adults & children/

  • Globally, there are 90 recruiting observational studies for Multiple sclerosis, including 3 studies on medical devices at ClinicalTrials.gov.
  • World leaders: the USA – 46, France/Germany – 14, Canada – 9 recruiting studies.
  • CEE leaders: Slovakia – 3, Austria/the Czech Republic – 2, Hungary – 1 recruiting study.

Non-interventional studies including children /pediatric, in children & adults/

  • Globally, there are 24 recruiting observational studies for Multiple sclerosis; no studies on medical devices at ClinicalTrials.gov.
  • World leaders: the USA – 14, Germany – 5, Australia/France – 4 recruiting studies.
  • CEE leaders: Austria/the Czech Republic – 1 recruiting study.

NB! The cities located on the non-controlled territories of Ukraine are not included in the statistics.

Publications of

Sergii Gromov

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