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Venous thromboembolism (VTE)

Without prevention, the rate of objectively confirmed hospital deep vein thrombosis (DVT) reaches approximately 10-40% among patients in general surgery and 40 -60% after major orthopedic operations. Up to 25-30% blood clots strikes deep veins, and can lead to pulmonary thromboembolism (PE). In surgical and orthopedic department PE is the cause of about 10% in-patient deaths.

Standardization of medical care

  • The Order of the MoH of Ukraine of 15.06.2007 #329 “On approval of clinical protocols of medical care for the prevention of thrombotic complications in Surgery, Orthopedics and Traumatology, Obstetrics and Gynecology”Read more.

Clinical trials including adults /in adults, adults & children/

  • Globally, there are 58 (Phase I – 6, Phase IV – 11) recruiting clinical trials for venous thromboembolism registered at ClinicalTrials.gov.
  • World leaders: the USA – 32, France – 15, Canada – 11 recruiting trials.
  • CEE leaders: the Russian Federation – 7, Austria – 5, Bulgaria/Lithuania/Poland – 3 recruiting trials.
  • Ukraine: Not yet recruiting – 0; Recruiting – 2; Active, not recruiting – 0 clinical trials.
    • The country experience includes 25 Phase II and III clinical trials totally.
    • 2 recruiting Phase III clinical trials are conducted on 34 clinical sites in 16 cities: Kharkiv/Kyiv – 7, Odesa/Zaporizhia – 3, Lviv/Sumy – 2, 10 other cities – 1 site.

Clinical trials on medical devices

  • Globally, there are 6 (Phase I – 0) recruiting clinical trials.
  • World leaders: the USA – 3, the United Kingdom – 2, the Russian Federation – 1 recruiting trial.
  • CEE leaders: the Russian Federation only – 1 recruiting clinical trial.

clinical trials for VTE including adults in CEE, August 2017

clinical trials for VTE including adults in Ukraine, August 2017

clinical sites in trials for VTE including adults in Ukraine, August 2017


Clinical trials including children /pediatric, in children & adults/

  • Globally, there are 16 (Phase I – 4, Phase IV – 2) recruiting clinical trials for venous thromboembolism registered at ClinicalTrials.gov.
  • World leaders: the USA – 12, Canada – 10, Germany – 7 recruiting trials.
  • CEE leaders: Austria/the Russian Federation – 6, Bulgaria/Lithuania/Poland/Ukraine – 3 recruiting trials.
  • Ukraine: Not yet recruiting – 0; Recruiting – 3; Active, not recruiting – 0 clinical trials.
    • The country experience includes 3 Phase III and IV recruiting clinical trials conducted on 7 clinical sites in 5 cities: Kyiv/Lviv – 2, Dnipro/ Vinnytsia/Zaporizhia – 1 site.

Clinical trials on medical devices

  • Globally, there are 2 (Phase I – 0) recruiting clinical trials.
  • World leaders: the USA/Saudi Arabia – 1 recruiting trial.
  • CEE leaders: no recruiting trials.

clinical trials for VTE including children in CEE, August 2017

clinical trials for VTE including children in Ukraine, August 2017

clinical sites in trials for VTE including children in Ukraine, August 2017


Non-interventional studies including adults /in adults, adults & children/

  • Globally, there are 37 (on medical devices – 1) recruiting observational studies for venous thromboembolism registered at ClinicalTrials.gov.
  • World leaders: Italy – 7, France/the USA – 6, Germany – 5 recruiting studies.
  • CEE leaders: the Russian Federation/Slovakia – 1 recruiting study.

Non-interventional studies including children /pediatric, in children & adults/

  • Globally, there are 13 (on medical devices – 0) recruiting observational studies for venous thromboembolism registered at ClinicalTrials.gov.
  • World leaders: Germany/France/Japan/the USA – 2 recruiting studies.
  • CEE leaders: no recruiting studies.

NB! The cities located on the non-controlled territories of Ukraine are not included in the statistics.

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Publications of

Sergii Gromov

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